In the present investigation two different polymers are used for the preparation of sustained release tablets HPMCK15M guar gum xanthan gum and Ethyl cellulose are selected Uniformity of weight hardness, friability and  assay of all the prepared 8 formulations were found within the official and fixed limits. Drug release studies were performed with the help of in vitro dissolution based on the dissolution data the best formulation was selected Colon release tablets of Metranidazole increases the therapeutic efficacy of the drug.

Silver Nanoparticles synthesis is an expanding area of research due to their properties and possible applications in several novel technologies. AgNPs are Essential in the biomedical field to diagnosis, treatments, mode of drug delivery and in bioremediation applications. The present research work was focussed on the biocompatible and the drug releasing nature of PEGylated silver nanoparticles (PEGylated AgNPS) synthesized from the ethanolic leaves extract of Volkameria inermis. The biocompatibility was studied in red blood cells collected from human healthy volunteers. In which, haemoglobin release analysis and the morphology of RBC was observed. The PEGylated AgNPS was found to be hemocompatible at the tested concentrations. Further, the cells does not show any morphological changes indicating the biocompatible nature. The drug release study followed at three different pH conditions i.e., pH 7.4, 6.8 and 5.5. The study resulted that PEGylated AgNPs showed an obvious pH related release behaviour. The drug release was found to be more rapid and sensitive at endosomal pH (pH 5.5). Hence, these nanoparticles are much biocompatible, environmentally safe and can be utilized in many medical applications.

The goal of this study is to use the Agar well diffusion method to test the antibacterial activity of leaves of Adina cordifolia (Rubiaceae family) against bacterial pathogens. The pharmacological activity of the chosen herbs, which are often utilised in traditional medicine, was shown to be extensive. Ethanol extracts of Adina cordifolia leaves were tested for antibacterial activity against Gram negative bacteria E. coli and Gram positive bacteria S. aureus bacterial strains at concentrations of 25mg/ml, 50mg/ml, 75mg/ml and 100mg/ml. The results revealed that ethanolic plant extracts with a concentration of 100 mg /ml were more effective against E.coli than S. aureus. The findings showed that the plant has potent antibacterial properties and might be a new source of antibiotics.

Many medicinal plants are a rich source of medications that have been prescribed in several medical treaties for the treatment of various ailments, either separately or in combination. Adina Cordifolia (Roxb.) is a plant found in India, Ceylon, Thailand, and Burma, where it grows in mixed deciduous woods and is used by traditional healers to cure chronic cough, as well as jaundice, stomachache, appetite, and stomach swelling. The roots are astringent and constipating, making them effective in the treatment of diarrhoea and dysentery. The bark is aphrodisiac, tonic, diuretic, bitter, astringent, refrigerant, vulnerary, diuretic, demulcent, aphrodisiac, and aphrodisiac. It can help with pitta vitiation, wounds and ulcers, straangury, skin illness, gastropathy, fever, and a burning feeling. Adina cordifolia is reported in the literature as having a wide range of therapeutic purposes. It's been used before. Oleoresin, essential oil, cellulose, and sitosterol are chemical elements of Adina Cordifolia Root and Bark. Adina cordifolia bark powder was dried in the shade.

Background and objectives: Dolichos lablab has been refered in Indian traditional medicine system (Ayurveda) for treatment of various disorders. In the present study extracts of Dolichos lablab studied for its anti inflammatory activity in animal models of inflammation. Materials and methods: Methanolic extracts of complex product prepared from dried leaves of Dolichos lablab plant. In the present study, the anti inflammatory effect of MLELP was examined using two behavioural models, the formalin induced edema model and egg white induced edema model in wister albino rats and one in-vitro model human red blood cell membrane protection assay. Results: The in-vitro anti-inflammatory studies such as HRBCMP assay shows satisfactory results, the concentration of extract increases the percentage of membrane protection, so they shows the dose dependent action. In FIE and EWIE demonstrated a dose dependent, statistically reduction in paw edema that was comparable to Diclophenac sodium (10mg/kg). The effect of 400mg/kg of MLELP was better than 200mg/kg of MLELP. The effect of 400mg/kg MLELP was significant when compared to vehicle treated group. In vitro study, MLELP in the dose of 200mg/kg and 400mg/kg showed decreased inhibition of edema when compared to that of normal. Plant extract at dose of 400mg/kg showed increases human red blood cell membrane protection, which is nearly equal to that of standard. Conclusion: The methanolic extract of Dolichos lablab leaves possessed significant in-vitro and in-vivo anti inflammatory activity in animal models.