The aim of the present study was to formulate and evaluate metronidazole containing thermosensitive bioadhesive gel for vaginal drug delivery to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginosis. polycarbophil and carbopol 934 showed optimum gelation temperature, gelation time, viscosity, bioadhesive strength with sustained drug release for 12 hrs. The optimized formulation (F8) showed insignificant change in physical property and drug content when stability testing was carried out at 25ºC/60% RH for 3 months.

In this research work, an improved RP-HPLC method was developed for the simultaneous estimation of Rosuvastatin, Aspirin and Clopidogrelin pharmaceutical fixed dosage form. There are various mobile phase and stationary phase tried among these the proposed reverse phase liquid chromatographic method was performed phenomenex® Gemini C18 column (150 x 4.6mm i.d., 5µm) and Acetonitrile: Methanol: 0.1% of Triethylamine (45:05:50, v/v), pH of the aqueous phase adjusted at to 3.0 with 10% orthophosphoric acid at a 1.0ml/min of flow rate. The peak measurement was performed by UV-detector at λmax of 235nm based on the peak area with linear calibration curves established at concentration of 2-10µg/ml for aspirin, clopidogrel and 1-5µg/ml for rosuvastatin (where R2> 0.999 for all three drugs). The overall runtime was achieved within 10 minutes. The improved method was validated according to International Conference on Harmonisation (ICH) guidelines to confirm specificity, linearity, accuracy and precision. The proposed validated method was successfully applied for the analysis of API and fixed dosage form.

Magnetic liposomes excels limitations that are associated with liposomes therefore they have procured enhanced attention as novel drug delivery system. Magnetic nanoparticles provide increase in the drug release and helps in monitoring therapy. The main objective of this article includes the study of novel advances to enhance the sequential release of different therapeutic agents. Magnetic liposome are spherical vesicles in which the drug can be encapsulated either in the bilayer of lipids or in the vesicle’s core. This review summarizes about the methods used in preparation of magnetic liposomes and various bio medical applications of the same. This article also includes the recent advances used in magnetic liposomes like thermo therapeutic strategies. Protein and gene delivery is another approach where proteins are used to prevent hydrolysis and enzymatic degradation and increases stability of the drug. Magnetic liposomes resulted in successful delivery of drugs to the heart with severe myocardial infraction.